Endocrine Abstracts

Insulin hypersecretion during oral or intravenous glucose tolerance test (OGTT, ivGTT) was described previously in women with polycystic ovary syndrome (PCOS). Little attention was given to the regulation of insulin secretion in these subjects. We aimed to study the secretion of incretins (glucose-dependent insulinotropic polypeptide, GIP, glucagon-like peptide 1, GLP-1), during OGTT in normoglucose-tolerant PCOS women.After signing written informed cons...

Introduction: Melatonin plays a key role in the circadian timing system. The question remains whether changes in endogenous melatonin may be associated with food intake. Orexin and ghrelin are involved in the regulation of energetic homeostasis. Therefore, we decided to obtain more detailed data on the circadian changes of orexin, ghrelin and melatonin for identification of the changes in these hormones to food intake and day-time, together with glycemic and C-peptide levels.<...

Osteoprotegerin (OPG) is a potent inhibitor of osteoclastic bone resorption. Besides osteoblasts, OPG is expressed by both endothelial and vascular smooth muscle cells. Moreover, elevated serum OPG has been found in conditions associated with insulin resistance such as obesity, diabetes and/or Cushing syndrome.The aim of the present study was to investigate the relationship between serum OPG and insulin resistance in women with polycystic ovary syndrome ...

Detailed information on adrenal function in autoimmune Type 1 diabetes with onset in adults is still lacking. This work aimed at gathering own data on adrenal response to low-dose (1 μg) ACTH in blood and saliva.Twenty-three diabetics were investigated; age 44±10 yrs (mean ± S.D.), age at diagnosis 28.5±10 yr, disease duration 15±8 yr, BMI 24.5±2.7 kg/cm2, HbA1c 7.2±1.2%....

Aim: To examine the secretion of insulin and glucagon in PCOS in the context of insulin sensitivity.Patients and methods: 13 healthy women (BMI 21.8(2.2) kg/m2), 21 PCOS without family history of DM2 (FH-); BMI 24.3 (4.4) kg/m2 and 16 PCOS with the 1st degree relative affected by DM2 (FH+); BMI 26.7 (4.2) kg/m2. Euglyceamic hyperinsulinaemic clamp (1mIU kg−1.min−1; with the determination ...

Aim and background: Retinol binding protein 4 (RBP 4) is an adipocyte-secreted molecule causing insulin resistance in transgenic animals. RBP was increased in subjects with impaired glucose tolerance and diabetes type 2. The levels of RBP-4 in PCOS were not investigated till now.Subjects and methods16 lean PCOS (BMI 21.4 (1.75) kg/m2, age 24.1 (4.1) years), 25 obese PCOS (BMI 30.3 (4.8) kg/m2, age 26.3 (5.0) years) and 13 healthy wo...

A 64 year old man presented with confusion and agitation following diarrhoea for 48 hours. He had a background history of hypertension, type 2 diabetes, depression and had a normal sodium concentration of 135 mmol/L a year prior to admission. His medications included bendroflumethiazide and sertraline in addition to metformin, diclofenac sodium, aspirin, simvastatin, nifedipine and enalapril. On examination he was conscious but confused. He was afebrile with a blood pressure o...

A 44-year-old man referred with erectile dysfunction was found to have hypogonadotrophic hypogonadism (HH), but otherwise apparently normal anterior pituitary function (LH 1.6 & FSH 2.7 IU/l; T 3.4 & cortisol 516 nmol/l; PRL 103, GH 5.5 & TSH 2.8 mU/l; f-T4 13, f-T3 4.8 & f-T 128 pmol/l; ferritin 103 ug/l). He appeared normally virilised, with central obesity (BMI 36 kg.m−2, collar size 46 cm) and symptomatic sleep apnoea (SA). MRI showed a rig...

IntroductionTrue resistance to cabergoline in patients with hyperprolactinaemia has only rarely been reported. We describe a patient with macroprolactinoma who initially responded to cabergoline, but then developed a progressive increase in PRL levels.Clinical caseA 78-year-old male presenting with headache and left temporal hemianopia was found to have a macroprolactinoma with suprasellar/cavernous sinus ext...

Introduction: Androgenetic alopecia (AGA) is the most common cause of balding in men. AGA is the risk factor of cardiovascular diseases, glucose metabolism disorders and also the risk of benign prostethyperplasia and prostate carcinoma. Polycystic ovary syndrome (PCOS) and metabolic syndrome are the risk factors of insulin resistance, obesity and diabetes mellitus. The genetic autosomal trait of PCOS initiated a hypothesis about the existence of a male equivalent of PCOS. Prem...